Drugs of Abuse: Identification of Positional Isomers by Solid-Phase GC-IRLisa Malette
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Drug exhibits have become more challenging over the years due to an increase in complex synthetic substances with many positional isomer and diastereomer possibilities. This presentation introduced solid phase deposition GC-FTIR as a technique which allows for improved specificity and reduced uncertainty in identification of regioisomers, diastereomers, analogs, and other closely related compounds such as fentanyl analogs, pseudoephedrine/ephedrine, phenethylamines, and synthetic cannabinoids.
When compared with mass spectrometry, infrared spectroscopy is able to readily provide detailed chemical information for differential analysis at a higher level of specificity and discrimination that is often unattainable through the use of tandem or high-resolution mass spectrometry techniques. Coupling the separation power of gas chromatography with the identification ability of infrared spectroscopy affords complementary information based on the retention behavior of the analytes and their spectral fingerprints.
Moreover, solid deposition FTIR enables improved sensitivity and resolution over conventional gas phase IR (light pipe), scaling down the limit of identification to the nanogram scale. Spectra obtained from solid phase deposition GC-FTIR analysis can be searched against commercially available ATR libraries, as well as being used to build in-house spectral libraries.
Detailed Learning Objectives:
1. Understand the technology behind solid deposition IR coupled with GC
2. Gain insight into the differences between gas phase IR and solid phase IR
3. Understand the capability to discriminate between isobaric molecules
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